Megadose bolus heparin as reperfusion therapy for acute myocardial infarction: Results of the HEAP pilot study
نویسندگان
چکیده
منابع مشابه
Reperfusion therapy of acute myocardial infarction.
I N 1979, DUCKERT reviewed the completed trials of intravenous (IV) thrombolytic therapy in acute myocardial infarction (MI) for this journal.’ Duckert stated in his review, “It is fair to conclude that today the value of thrombolytic treatment of acute MI has not been established.” Since this review, dramatic advances have been made in the understanding of pathogenesis of MI, knowledge of thro...
متن کاملHigh dose heparin as pretreatment for primary angioplasty in acute myocardial infarction: the Heparin in Early Patency (HEAP) randomized trial.
OBJECTIVES In the Heparin in Early Patency (HEAP) pilot study a beneficial effect of high-dose heparin on early patency in acute myocardial infarction (MI) was observed in a matched-control study. BACKGROUND High dose bolus intravenous injection of heparin may achieve lysis of coronary thrombi and could enhance early patency of the infarct related vessel in patients with MI scheduled for prim...
متن کاملA randomized pilot trial of brief versus prolonged heparin after successful reperfusion in acute myocardial infarction.
Controversy exists as to whether and how long heparin treatment is necessary after infarct vessel recanalization. To determine the role of heparin, patients with suitable angiographic features after reperfusion therapy were randomly allocated to receive a brief infusion of intravenous heparin for less than or equal to 24 hours (group 1), adjusted to a partial thromboplastin time of 2 times cont...
متن کاملReperfusion Strategies for Acute Myocardial Infarction: Mechanical vs. Thrombolytic Therapy
Management of patients with acute myocardial infarction represents a great challenge to emergency physicians, a task more recently complicated by the myriad of potential treatment options available. The goal of reperfusion therapy in patients with ST segment elevation myocardial infarction (STEMI) is the safest, earliest and most complete restoration of normal (TIMI-3) flow in the infarct relat...
متن کاملAcute Myocardial Infarction Low Molecular Weight Heparin (Dalteparin) as Adjuvant Treatment to Thrombolysis in Acute Myocardial Infarction—A Pilot Study: Biochemical Markers in Acute Coronary Syndromes (BIOMACS II)
METHODS In 101 patients dalteparin/placebo 100 IU/kg was given just before streptokinase and a second injection 120 IU/kg after 12 h. Monitoring with continuous vector-ECG was done to obtain signs of early reperfusion and later ischemic episodes. Blood samples for myoglobin were obtained at start and after 90 min to evaluate signs of reperfusion. Coronary angiography was performed after 20–28 h...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1996
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(96)80223-3